Transmitted causes ("causes of causes") tend not to be systematically analysed. the wheel of causation de emphasizes the agent as the sole cause of disease. The Wheel of Causation The Wheel of Causation (Mausner & Kramer, 1985) de-emphasizes the agent as the sole cause of disease, while emphasizing the interplay of physical, biological and social environments (Figure 7). Two conceptual questions currently face epidemiology, both relating to causation. Introduction. Theories of causation • Old theories • Modern theories – germ theory – multifactorial causation – socioeconomic, cultural, genetic, psychological – epidemiological triad (tetrad) – web of causation – wheel of causation 6First MBBS – Epidemiology series 7. Figure 0: The Wheel of Causation One application of The Wheel of Causation 'Multiple causation' is the canon of contemporary epidemiology, and its metaphor and model is the 'web of causation.' The wheel of causation, an alternative model, according to Harkness and DeMarco (2012), “…de-emphasizes the agent as the sole cause of disease, whereas it emphasizes the interplay of physical, biological, and social environments” (p.94). For long, man was groping in darkness about the causation of disease. First, how should it handle certain diseases, which appear to be etiologically more complex than the infections and deficiencies by which epidemiology made its name?In particular, chronic non-communicable diseases (CNCDs) account for a larger proportion of deaths, at least in the … The surrounding wheel represents the environment and comprises biological, social, and physical dimensions. When the cause is determined, medical professionals learn more about which groups of people are prone to developing or contracting a certain disease. Models of Disease Causation, Germ Theory, Epidemiological Triad, Web and Wheel of Disease Causation. First articulated in a 1960 U.S. epidemiology textbook, the 'web' remains a widely accepted but poorly elaborated model, reflecting in part the contemporary stress on epidemiologic methods over epidemiologic theories of disease causation. Methods of diagrammatic modelling have been greatly developed in the past two decades. ... causation is the theory that something happened due to a given cause. The purpose is to identify risk factors that can be modified. Cause and effect basically. The wheel consists of a hub that represents the host and its human characteristics such as genetic makeup, personality, and immunity. Abstract. 1. The wheel allows for a multiple-causation theory of disease, it is more useful for analyzing complex chronic conditions. Outside the context of infectious diseases, systematic use of diagrams in epidemiology has been mainly confined to the analysis of a single link: that between a disease outcome and its proximal determinant(s). Alzheimer’s disease will be the epidemic of the twenty-first century (1,2). Several theories were advanced from time to time to explain disease causation such as the supernatural theory of disease, the theory of humors by Greeks and Indians, the theory of contagion, the miasmatic theory which attributed disease to noxious air and vapours, the theory of spontaneous generation, etc. Web of causation models are especially helpful for finding the causes of genetic diseases. It also brings genetics into the mix. 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